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In this population: Higher waist-to-hip ratio increased risk up to 7.7-fold (especially peri-menopausally) Greater body fat percentage, waist-height ratio, or visceral fat area each increased risk around 4-fold Higher body mass index (BMI) or waist circumference, each, increased risk almost 3-fold Because obesity is associated with significant changes in immunometabolic and hormonal parameters, it seems likely that the strength of these findings will be confirmed in other populations

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Research areas include adipocyte differentiation, diet-induced obesity models, cellular energy balance, and epigenetic methylation pathways