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This indicated that the TrxR1/Gsr-null livers excrete much more oxidized GSSG than do wild type livers, which likely is critical for sustaining the reduced state of the intracellular [GSH/GSSG] redox couple in the absence of GSSG-reductase activity [107]

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Indeed, ZF proteins adopt to a wide diversity of folds that differ in the type and arrangement of metal ligands in the primary structure, e.g., CCHH, CCCH and CCHC, respectively, suggesting strongly divergent evolutionary solutions to a common protein folding problem (Figure 3A-D)